My employer refuses to upgrade to Cisco's AnyConnect VPN server, so, like many out there, I've had no VPN for my Vista x64 machine at home. The other day, I bit the bullet and installed Virtual PC to run VPN in a virtual machine. I installed Vista x86 in the VM and away I went.
Let me just say that this is the way I should have been using VPN years ago. Not only can I use it on my big home computer monitor (as opposed to my small work laptop), but I can still use my normal cable modem and home network rather than routing everything through VPN.
So even if my employer buys the latest VPN software, chances are I'm going to continue using it inside of a VM. It's a great setup.